X-ray diffraction
1.8Å resolution

Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain


Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 356 amino acids
Theoretical weight: 41.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P28482 (Residues: 8-360; Coverage: 98%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:
Astrocytic phosphoprotein PEA-15 Chain: B
Molecule details ›
Chain: B
Length: 97 amino acids
Theoretical weight: 11.24 KDa
Source organism: Cricetulus griseus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9Z297 (Residues: 1-96; Coverage: 74%)
Gene name: PEA15
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 73.478Å b: 205.334Å c: 57.746Å
α: 90° β: 90° γ: 90°
R R work R free
0.187 0.185 0.222
Expression system: Escherichia coli BL21(DE3)