X-ray diffraction
3Å resolution

Crystal structure and mechanism of activation of TBK1

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase TBK1 Chain: A
Molecule details ›
Chain: A
Length: 659 amino acids
Theoretical weight: 75.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q9UHD2 (Residues: 2-657; Coverage: 90%)
Gene names: NAK, TBK1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3221
Unit cell:
a: 135.76Å b: 135.76Å c: 86.5Å
α: 90° β: 90° γ: 120°
R R work R free
0.264 0.262 0.31
Expression system: Spodoptera frugiperda