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Crystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA

X-ray diffraction
2.752Å resolution
PDB entry 4iuf coloured by chain, front view.
PDB entry 4iuf coloured by chain, side view.
PDB entry 4iuf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TAR DNA-binding protein 43 and DNA
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Multimeric state: hetero dimer
Accessible surface area: 6243.95 Å2
Buried surface area: 1446.66 Å2
Dissociation area: 723.33 Å2
Dissociation energy (ΔGdiss): -8.04 kcal/mol
Dissociation entropy (TΔSdiss): 9.38 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117663

Macromolecules

TAR DNA-binding protein 43
Chain: A
Length: 77 amino acids
Theoretical weight: 8.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13148 (Residues: 103-179; Coverage: 19%)
Gene names: TARDBP, TDP43
Pfam: RNA recognition motif
InterPro:
CATH: Alpha-Beta Plaits
TAR DNA-binding protein 43 in PDB entry 4iuf, assembly 1, front view.
TAR DNA-binding protein 43 in PDB entry 4iuf, assembly 1, side view.
TAR DNA-binding protein 43 in PDB entry 4iuf, assembly 1, top view.
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DNA chain B
Name: 5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3'
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 9 nucleotides
Theoretical weight: 2.88 KDa
5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3' in PDB entry 4iuf, assembly 1, front view.
5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3' in PDB entry 4iuf, assembly 1, side view.
5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3' in PDB entry 4iuf, assembly 1, top view.
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