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Crystal structure of catalytic domain of human beta1,4galactosyltransferase 7 in closed conformation in complex with manganese and UDP

X-ray diffraction
2.3Å resolution
PDB entry 4irq coloured by chain, front view.
PDB entry 4irq coloured by chain, side view.
PDB entry 4irq coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-1,4-galactosyltransferase 7
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Multimeric state: monomeric
Accessible surface area: 11212.56 Å2
Buried surface area: 1250.82 Å2
Dissociation area: 207.07 Å2
Dissociation energy (ΔGdiss): -3.08 kcal/mol
Dissociation entropy (TΔSdiss): 1.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193684
Assembly 2
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Assembly Name: Beta-1,4-galactosyltransferase 7
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Multimeric state: monomeric
Accessible surface area: 11107.91 Å2
Buried surface area: 1247.98 Å2
Dissociation area: 206.86 Å2
Dissociation energy (ΔGdiss): -3.46 kcal/mol
Dissociation entropy (TΔSdiss): 1.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193684
Assembly 3
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Assembly Name: Beta-1,4-galactosyltransferase 7
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Multimeric state: monomeric
Accessible surface area: 11271.31 Å2
Buried surface area: 1247.63 Å2
Dissociation area: 207.41 Å2
Dissociation energy (ΔGdiss): -3.67 kcal/mol
Dissociation entropy (TΔSdiss): 1.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193684
Assembly 4
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Assembly Name: Beta-1,4-galactosyltransferase 7
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Multimeric state: monomeric
Accessible surface area: 11187.76 Å2
Buried surface area: 1247.39 Å2
Dissociation area: 206 Å2
Dissociation energy (ΔGdiss): -3.14 kcal/mol
Dissociation entropy (TΔSdiss): 1.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193684
Assembly 5
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Assembly Name: Beta-1,4-galactosyltransferase 7
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Multimeric state: homo dimer
Accessible surface area: 20536.95 Å2
Buried surface area: 4361.58 Å2
Dissociation area: 931.69 Å2
Dissociation energy (ΔGdiss): 4.07 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-193685
Assembly 6
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Assembly Name: Beta-1,4-galactosyltransferase 7
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Multimeric state: homo dimer
Accessible surface area: 20528.55 Å2
Buried surface area: 4346.28 Å2
Dissociation area: 925.34 Å2
Dissociation energy (ΔGdiss): 4.33 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-193685

Macromolecules

Beta-1,4-galactosyltransferase 7
Chains: A, B, C, D
Length: 251 amino acids
Theoretical weight: 29.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBV7 (Residues: 81-327; Coverage: 76%)
Gene names: B4GALT7, UNQ748/PRO1478, XGALT1
Pfam:
InterPro:
CATH: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Beta-1,4-galactosyltransferase 7 in PDB entry 4irq, assembly 1, front view.
Beta-1,4-galactosyltransferase 7 in PDB entry 4irq, assembly 1, side view.
Beta-1,4-galactosyltransferase 7 in PDB entry 4irq, assembly 1, top view.
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