Structure analysis

Crystal structure of catalytic domain of human beta1,4-galactosyltransferase-7 in open conformation with manganses and UDP

X-ray diffraction
2.1Å resolution
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 11100 Å2
Buried surface area: 1600 Å2
Dissociation area: 100 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): -13 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 11000 Å2
Buried surface area: 1000 Å2
Dissociation area: 100 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): -12 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: homo dimer
Accessible surface area: 20600 Å2
Buried surface area: 4100 Å2
Dissociation area: 750 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -37 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B
Length: 251 amino acids
Theoretical weight: 29.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBV7 (Residues: 81-327; Coverage: 76%)
Gene names: B4GALT7, UNQ748/PRO1478, XGALT1
Pfam: N-terminal domain of galactosyltransferase
InterPro:
CATH: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

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