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Auto-inhibited ERG Ets domain

X-ray diffraction
2.1Å resolution
PDB entry 4irh coloured by chain, front view.
PDB entry 4irh coloured by chain, side view.
PDB entry 4irh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transcriptional regulator ERG
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Multimeric state: homo dimer
Accessible surface area: 10374.23 Å2
Buried surface area: 1979.43 Å2
Dissociation area: 989.71 Å2
Dissociation energy (ΔGdiss): 9.22 kcal/mol
Dissociation entropy (TΔSdiss): 11.14 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-145751

Macromolecules

Transcriptional regulator ERG
Chain: A
Length: 129 amino acids
Theoretical weight: 15.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11308 (Residues: 280-405; Coverage: 26%)
Gene name: ERG
Pfam: Ets-domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Transcriptional regulator ERG in PDB entry 4irh, assembly 1, front view.
Transcriptional regulator ERG in PDB entry 4irh, assembly 1, side view.
Transcriptional regulator ERG in PDB entry 4irh, assembly 1, top view.
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