Structure analysis

Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC

X-ray diffraction
1.95Å resolution
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 24100 Å2
Buried surface area: 7900 Å2
Dissociation area: 550 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -38 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 214 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins

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Chain: B
Length: 223 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins

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Chain: H
Length: 55 amino acids
Theoretical weight: 6.12 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A015 (Residues: 101-151; Coverage: 12%)
Gene names: SAV0111, spa
InterPro:
CATH: Immunoglobulin FC, subunit C

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Chain: E
Length: 65 amino acids
Theoretical weight: 6.99 KDa
Source organism: Finegoldia magna
Expression system: Escherichia coli
UniProt:
  • Canonical: Q51918 (Residues: 476-537; Coverage: 6%)
InterPro: Protein L, Ig light chain-binding
CATH: Ubiquitin-like (UB roll)

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