4io8

X-ray diffraction
2.58Å resolution

Crystal structure of human HSP70 complexed with 4-{(2R,3S,4R)-5-[(R)-6-Amino-8-(3,4-dichloro-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxymethyl}-benzonitrile

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock 70 kDa protein 1B Chain: A
Molecule details ›
Chain: A
Length: 382 amino acids
Theoretical weight: 42.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DMV9 (Residues: 1-382; Coverage: 60%)
Gene names: HSP72, HSPA1B
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 58.68Å b: 53.973Å c: 70.796Å
α: 90° β: 101.07° γ: 90°
R-values:
R R work R free
0.172 0.169 0.222
Expression system: Escherichia coli