Function and Biology

Crystal structure of truncated Bovine viral diarrhea virus 1 E2 envelope protein

Source organism: Bovine viral diarrhea virus 1-NADL
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 4.6.1.19: Ribonuclease T(2)

Reaction catalysed:
(1a) RNA = an (RNA fragment)-3'-nucleoside-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA fragment)
Systematic name:
(RNA) 5'-hydroxy-ribonucleotide-3'-(RNA fragment)-lyase (cyclicizing; (RNA fragment)-3'- nucleoside-2',3'-cyclophosphate-forming and hydrolyzing)
Alternative Name(s):
  • Acid RNase
  • Acid ribonuclease
  • Base-non-specific ribonuclease
  • Escherichia coli ribonuclease I' ribonuclease PP2
  • Escherichia coli ribonuclease II
  • Non-base specific ribonuclease
  • Nonbase-specific RNase
  • Nonspecific RNase
  • RNAase CL
  • RNase (non-base specific)
  • RNase II
  • RNase M
  • RNase Ms
  • RNase T(2)
  • Ribonnuclease (non-base specific)
  • Ribonuclease (non-base specific)
  • Ribonuclease II
  • Ribonuclease M
  • Ribonuclease N(2)
  • Ribonuclease PP3
  • Ribonuclease T2
  • Ribonuclease U(4)
  • Ribonucleate 3'-oligonucleotide hydrolase
  • Ribonucleate nucleotido-2'-transferase (cyclizing)

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.21.113: Pestivirus NS3 polyprotein peptidase

Reaction catalysed:
Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites
Systematic name:
-
Alternative Name(s):
  • BDV NS3 endopeptidase
  • BVDV NS3 endopeptidase
  • Border disease virus NS3 endopeptidase
  • Bovine viral diarrhea virus NS3 endopeptidase
  • CSFV NS3 endopeptidase
  • Classical swine fever virus NS3 endopeptidase
  • P80

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF16329
Domain description: Pestivirus envelope glycoprotein E2
Occurring in:
  1. Envelope glycoprotein E2
The deposited structure of PDB entry 4ild contains 2 copies of Pfam domain PF16329 (Pestivirus envelope glycoprotein E2) in Envelope glycoprotein E2. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR042311
Domain description: Pestivirus envelope glycoprotein E2, domain D
Occurring in:
  1. Envelope glycoprotein E2
IPR032521
Domain description: Pestivirus envelope glycoprotein E2
Occurring in:
  1. Envelope glycoprotein E2
IPR042310
Domain description: Pestivirus envelope glycoprotein E2, domain B
Occurring in:
  1. Envelope glycoprotein E2

Structure domains

CATH CATH domains
2.60.40.4200
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Pestivirus envelope glycoprotein E2, C-terminal domain
Occurring in:
  1. Envelope glycoprotein E2
The deposited structure of PDB entry 4ild contains 2 copies of CATH domain 2.60.40.4200 (Immunoglobulin-like) in Envelope glycoprotein E2. Showing 1 copy in chain B.
2.60.40.3000
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Pestivirus envelope glycoprotein E2, domain B
Occurring in:
  1. Envelope glycoprotein E2
The deposited structure of PDB entry 4ild contains 2 copies of CATH domain 2.60.40.3000 (Immunoglobulin-like) in Envelope glycoprotein E2. Showing 1 copy in chain B.