Function and Biology

Human methemoglobin in complex with the second and third NEAT domains of IsdH from Staphylococcus aureus

Source organisms:
Biochemical function: metal ion binding
Biological process: cellular oxidant detoxification
Cellular component: blood microparticle

Sequence families

Pfam Protein families (Pfam)
PF05031
Domain description: Iron Transport-associated domain
Occurring in:
  1. Iron-regulated surface determinant protein H
The deposited structure of PDB entry 4ij2 contains 8 copies of Pfam domain PF05031 (Iron Transport-associated domain ) in Iron-regulated surface determinant protein H. Showing 2 copies in chain F.

PF20861
Domain description: Iron-regulated surface determinant protein H/B, linker domain
Occurring in:
  1. Iron-regulated surface determinant protein H
The deposited structure of PDB entry 4ij2 contains 4 copies of Pfam domain PF20861 (Iron-regulated surface determinant protein H/B, linker domain) in Iron-regulated surface determinant protein H. Showing 1 copy in chain F.

PF00042
Domain description: Globin
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
The deposited structure of PDB entry 4ij2 contains 2 copies of Pfam domain PF00042 (Globin) in Hemoglobin subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 4ij2 contains 2 copies of Pfam domain PF00042 (Globin) in Hemoglobin subunit beta. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR006635
Domain description: NEAT domain
Occurring in:
  1. Iron-regulated surface determinant protein H
IPR037250
Domain description: NEAT domain superfamily
Occurring in:
  1. Iron-regulated surface determinant protein H
IPR002337
Domain description: Hemoglobin, beta-type
Occurring in:
  1. Hemoglobin subunit beta
IPR002338
Domain description: Hemoglobin, alpha-type
Occurring in:
  1. Hemoglobin subunit alpha
IPR002339
Domain description: Hemoglobin, pi
Occurring in:
  1. Hemoglobin subunit alpha
IPR000971
Domain description: Globin
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
IPR009050
Domain description: Globin-like superfamily
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta
IPR012292
Domain description: Globin/Protoglobin
Occurring in:
  1. Hemoglobin subunit alpha
  2. Hemoglobin subunit beta