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Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R in sequence-specific complex with DNA

X-ray diffraction
1.7Å resolution
PDB entry 4ibu coloured by chain, front view.
PDB entry 4ibu coloured by chain, side view.
PDB entry 4ibu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cellular tumor antigen p53 and DNA
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Multimeric state: hetero octamer
Accessible surface area: 41192.93 Å2
Buried surface area: 12763.75 Å2
Dissociation area: 4,316.87 Å2
Dissociation energy (ΔGdiss): -2.43 kcal/mol
Dissociation entropy (TΔSdiss): 69.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117637

Macromolecules

Cellular tumor antigen p53
Chains: A, B, C, D
Length: 200 amino acids
Theoretical weight: 22.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04637 (Residues: 94-293; Coverage: 51%)
Gene names: P53, TP53
Pfam: P53 DNA-binding domain
InterPro:
CATH: Immunoglobulin-like
Cellular tumor antigen p53 in PDB entry 4ibu, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 4ibu, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 4ibu, assembly 1, top view.
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DNA chains E, F, G, H
Name: DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3')
Representative chains: E, F, G, H
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3') in PDB entry 4ibu, assembly 1, front view.
DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3') in PDB entry 4ibu, assembly 1, side view.
DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3') in PDB entry 4ibu, assembly 1, top view.
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