4i9x

X-ray diffraction
2.1Å resolution

Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Protein UL141 Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 25.11 KDa
Source organism: Human herpesvirus 5 strain Merlin
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6RJQ3 (Residues: 32-246; Coverage: 70%)
Gene name: UL141
Sequence domains: Herpes-like virus membrane glycoprotein UL141
Structure domains: Immunoglobulin-like
Tumor necrosis factor receptor superfamily member 10B Chains: C, D
Molecule details ›
Chains: C, D
Length: 127 amino acids
Theoretical weight: 14.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14763 (Residues: 58-184; Coverage: 33%)
Gene names: DR5, KILLER, TNFRSF10B, TRAILR2, TRICK2, UNQ160/PRO186, ZTNFR9
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 67.916Å b: 97.043Å c: 141.422Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.223 0.274
Expression system: Spodoptera frugiperda