X-ray diffraction
2.6Å resolution

Human Cytochrome P450 1A1 in complex with alpha-naphthoflavone


Function and Biology Details

Reactions catalysed:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O
A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytochrome P450 1A1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 491 amino acids
Theoretical weight: 55.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P04798 (Residues: 35-512; Coverage: 93%)
  • Best match: P04798-3 (Residues: 1-157)
Gene name: CYP1A1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

Cofactor: Ligand HEM 4 x HEM
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 65.003Å b: 195.491Å c: 235.855Å
α: 90° β: 90° γ: 90°
R R work R free
0.188 0.188 0.244
Expression system: Escherichia coli