PDBe 4i5p

X-ray diffraction
1.74Å resolution

Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK2 Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 35.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NYY3 (Residues: 57-360; Coverage: 44%)
Gene names: PLK2, SNK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 103.871Å b: 60.114Å c: 52.951Å
α: 90° β: 106.77° γ: 90°
R-values:
R R work R free
0.224 0.221 0.273
Expression system: Escherichia coli