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Nanobody ca1697 binding to the DHFR.folate binary complex

Source organisms:
Biochemical function: NADPH binding
Biological process: response to antibiotic
Cellular component: cytosol

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EC 1.5.1.3: Dihydrofolate reductase

Reaction catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
Systematic name:
5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
  • 7,8-dihydrofolate reductase
  • DHFR
  • Dihydrofolate reductase:thymidylate synthase
  • Dihydrofolic acid reductase
  • Dihydrofolic reductase
  • Folic acid reductase
  • Folic reductase
  • NADPH-dihydrofolate reductase
  • Pteridine reductase:dihydrofolate reductase
  • Tetrahydrofolate dehydrogenase
  • Thymidylate synthetase-dihydrofolate reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00186
Domain description: Dihydrofolate reductase
Occurring in:
  1. Dihydrofolate reductase
The deposited structure of PDB entry 4i13 contains 1 copy of Pfam domain PF00186 (Dihydrofolate reductase) in Dihydrofolate reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Protein ca1697 (nanobody)
IPR012259
Domain description: Dihydrofolate reductase
Occurring in:
  1. Dihydrofolate reductase
IPR001796
Domain description: Dihydrofolate reductase domain
Occurring in:
  1. Dihydrofolate reductase
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Protein ca1697 (nanobody)
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Protein ca1697 (nanobody)
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Protein ca1697 (nanobody)
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Protein ca1697 (nanobody)
IPR017925
Domain description: Dihydrofolate reductase conserved site
Occurring in:
  1. Dihydrofolate reductase
IPR024072
Domain description: Dihydrofolate reductase-like domain superfamily
Occurring in:
  1. Dihydrofolate reductase

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Protein ca1697 (nanobody)
The deposited structure of PDB entry 4i13 contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Protein ca1697 (nanobody). Showing 1 copy in chain B.
3.40.430.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Dihydrofolate Reductase, subunit A
Homology: Dihydrofolate Reductase, subunit A
Occurring in:
  1. Dihydrofolate reductase
The deposited structure of PDB entry 4i13 contains 1 copy of CATH domain 3.40.430.10 (Dihydrofolate Reductase, subunit A) in Dihydrofolate reductase. Showing 1 copy in chain A.

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