› 4hyy

X-ray diffraction
2.6Å resolution

Filament of octameric rings of DMC1 recombinase from Homo sapiens

Released:
DOI: 10.2210/pdb4hyy/pdb
PDB 4hyy coloured by chain and viewed from the front.
PDB 4hyy coloured by chain and viewed from the side.
PDB 4hyy coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structure of a filament of stacked octamers of human DMC1 recombinase.
Du L, Luo Y
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69 382-6 (2013)
PMID: 23545642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo octamer (preferred)
homo hexadecamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Meiotic recombination protein DMC1/LIM15 homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 265 amino acids
Theoretical weight: 29.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14565 (Residues: 84-340; Coverage: 76%)
Gene names: DMC1, DMC1H, LIM15
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P4
Unit cell:
a: 123.997Å b: 123.997Å c: 91.713Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.179 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing.
He et al. (2018)

1 mention without citation

Structure of a filament of stacked octamers of human DMC1 recombinase.
Du et al. (2013)