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Crystal structure of a response regulator spr1814 from Streptococcus pneumoniae reveals unique interdomain contacts among NarL family proteins

Source organism: Streptococcus pneumoniae R6
Biochemical function: metal ion binding
Biological process: regulation of DNA-templated transcription
Cellular component: protein-DNA complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00196
Domain description: Bacterial regulatory proteins, luxR family
Occurring in:
  1. Response regulator
The deposited structure of PDB entry 4hye contains 2 copies of Pfam domain PF00196 (Bacterial regulatory proteins, luxR family) in Response regulator. Showing 1 copy in chain A.

PF00072
Domain description: Response regulator receiver domain
Occurring in:
  1. Response regulator
The deposited structure of PDB entry 4hye contains 2 copies of Pfam domain PF00072 (Response regulator receiver domain) in Response regulator. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000792
Domain description: Transcription regulator LuxR, C-terminal
Occurring in:
  1. Response regulator
IPR001789
Domain description: Signal transduction response regulator, receiver domain
Occurring in:
  1. Response regulator
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Response regulator
IPR016032
Domain description: Signal transduction response regulator, C-terminal effector
Occurring in:
  1. Response regulator
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Response regulator
IPR011006
Domain description: CheY-like superfamily
Occurring in:
  1. Response regulator

Structure domains

CATH CATH domains
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Response regulator
The deposited structure of PDB entry 4hye contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Response regulator. Showing 1 copy in chain A.
3.40.50.2300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Response regulator
The deposited structure of PDB entry 4hye contains 2 copies of CATH domain 3.40.50.2300 (Rossmann fold) in Response regulator. Showing 1 copy in chain A.

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