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Structure of HLA-A68 complexed with a tumor antigen derived peptide

Source organism: Homo sapiens
Biochemical function: protein homodimerization activity
Biological process: negative regulation of forebrain neuron differentiation
Cellular component: HFE-transferrin receptor complex

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EC 5.3.3.12: L-dopachrome isomerase

Reaction catalysed:
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
Systematic name:
L-dopachrome keto-enol isomerase
Alternative Name(s):
  • DCF
  • DCT
  • Dopachrome Delta(7),Delta(2)-isomerase
  • Dopachrome Delta-isomerase
  • Dopachrome conversion factor
  • Dopachrome isomerase
  • Dopachrome keto-enol isomerase
  • Dopachrome oxidoreductase
  • Dopachrome rearranging enzyme
  • Dopachrome tautomerase
  • Dopachrome-rearranging enzyme
  • L-dopachrome-methyl ester tautomerase
  • TRP
  • TRP-1
  • TRP-2
  • TRP2
  • Tryosinase-related protein-2
  • Tyrosinase-related protein 2

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
The deposited structure of PDB entry 4hx1 contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 4hx1 contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 1 copy in chain B.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 4hx1 contains 1 copy of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR015707
Domain description: Beta-2-Microglobulin
Occurring in:
  1. Beta-2-microglobulin
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
The deposited structure of PDB entry 4hx1 contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 4hx1 contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 1 copy in chain B.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 4hx1 contains 1 copy of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

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