PDBe 4hwt

X-ray diffraction
2.3Å resolution

Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Threonine--tRNA ligase, cytoplasmic Chains: A, B
Molecule details ›
Chains: A, B
Length: 413 amino acids
Theoretical weight: 48.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P26639 (Residues: 321-723; Coverage: 56%)
Gene name: TARS
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P41212
Unit cell:
a: 73.897Å b: 73.897Å c: 357.587Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.257
Expression system: Escherichia coli BL21