EC 2.3.2.27: RING-type E3 ubiquitin transferase
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
- RING E3 ligase
- Ubiquitin transferase RING E3
GO terms
Biochemical function:
Biological process:
- positive regulation of plasma membrane repair
- positive regulation of substrate adhesion-dependent cell spreading
- protein localization to plasma membrane
- positive regulation of focal adhesion assembly
- positive regulation of stress fiber assembly
- regulation of neurogenesis
- positive regulation of transcription by RNA polymerase II
- positive regulation of exocytosis
- positive regulation of GTPase activity
- mRNA transcription by RNA polymerase II
- positive regulation of plasminogen activation
- vesicle budding from membrane
- membrane raft assembly
Protein family (Pfam)
InterPro annotations
CATH domain