PDBe 4hrh

X-ray diffraction
3Å resolution

Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide


Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
hetero 12-mer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Annexin A2; Protein S100-A10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 13.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P60903 (Residues: 1-93; Coverage: 96%)
  • Canonical: P07355 (Residues: 2-16; Coverage: 4%)
Gene names: ANX2, ANX2L4, ANX2LG, ANXA2, CAL1H, CAL1L, CLP11, LPC2D, S100A10
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand
Helicase-like transcription factor Chains: C, D
Molecule details ›
Chains: C, D
Length: 14 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q14527 (Residues: 26-39; Coverage: 1%)
Gene names: HIP116A, HLTF, RNF80, SMARCA3, SNF2L3, ZBU1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P4332
Unit cell:
a: 145.106Å b: 145.106Å c: 145.106Å
α: 90° β: 90° γ: 90°
R R work R free
0.222 0.22 0.263
Expression systems:
  • Escherichia coli
  • Not provided