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Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine

X-ray diffraction
2Å resolution
PDB entry 4hos coloured by chain, front view.
PDB entry 4hos coloured by chain, side view.
PDB entry 4hos coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon-induced protein with tetratricopeptide repeats 5 and RNA
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Multimeric state: hetero dimer
Accessible surface area: 23007.81 Å2
Buried surface area: 915.09 Å2
Dissociation area: 102.6 Å2
Dissociation energy (ΔGdiss): 13.57 kcal/mol
Dissociation entropy (TΔSdiss): -1.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171640

Macromolecules

Interferon-induced protein with tetratricopeptide repeats 5
Chain: A
Length: 482 amino acids
Theoretical weight: 55.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13325 (Residues: 1-482; Coverage: 100%)
Gene names: IFIT5, ISG58, RI58
Pfam:
InterPro:
CATH: Tetratricopeptide repeat domain
Interferon-induced protein with tetratricopeptide repeats 5 in PDB entry 4hos, assembly 1, front view.
Interferon-induced protein with tetratricopeptide repeats 5 in PDB entry 4hos, assembly 1, side view.
Interferon-induced protein with tetratricopeptide repeats 5 in PDB entry 4hos, assembly 1, top view.
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RNA chain X
Name: RNA (5'-R(*(UTP)P*UP*UP*U)-3')
Representative chains: X
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 4 nucleotides
Theoretical weight: 1.34 KDa
RNA (5'-R(*(UTP)P*UP*UP*U)-3') in PDB entry 4hos, assembly 1, front view.
RNA (5'-R(*(UTP)P*UP*UP*U)-3') in PDB entry 4hos, assembly 1, side view.
RNA (5'-R(*(UTP)P*UP*UP*U)-3') in PDB entry 4hos, assembly 1, top view.
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