X-ray diffraction
2.95Å resolution

Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP


Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphatidylinositol 4-kinase type 2-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 384 amino acids
Theoretical weight: 43.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9BTU6 (Residues: 78-453; Coverage: 79%)
Gene name: PI4K2A
Sequence domains: Phosphatidylinositol 3- and 4-kinase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I422
Unit cell:
a: 191.824Å b: 191.824Å c: 157.543Å
α: 90° β: 90° γ: 90°
R R work R free
0.21 0.208 0.251
Expression system: Escherichia coli BL21(DE3)