PDBe 4hkc

X-ray diffraction
2.2Å resolution

14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide

Released:
Source organism: Homo sapiens
Primary publication:
Characterization of 14-3-3-ζ interactions with integrin tails.
OpenAccess logo J. Mol. Biol. (2013)
PMID: 23763993

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein zeta/delta Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 28.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63104 (Residues: 1-245; Coverage: 100%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain
Integrin alpha-4 Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13612 (Residues: 1003-1032; Coverage: 3%)
Gene names: CD49D, ITGA4

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 89.03Å b: 111.6Å c: 72.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.239
Expression systems:
  • Escherichia coli
  • Not provided