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Crystal structure analysis of apo-GroEL structure

Source organism: Escherichia coli
Biochemical function: ATP-dependent protein folding chaperone
Biological process: chaperone cofactor-dependent protein refolding
Cellular component: GroEL-GroES complex

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EC 5.6.1.7: Chaperonin ATPase

Reaction catalysed:
ATP + H(2)O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide
Systematic name:
ATP phosphohydrolase (polypeptide-unfolding)
Alternative Name(s):
  • Chaperonin

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00118
Domain description: TCP-1/cpn60 chaperonin family
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 4hel contains 14 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in Chaperonin GroEL. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001844
Domain description: Chaperonin Cpn60/GroEL
Occurring in:
  1. Chaperonin GroEL
IPR027409
Domain description: GroEL-like apical domain superfamily
Occurring in:
  1. Chaperonin GroEL
IPR027410
Domain description: TCP-1-like chaperonin intermediate domain superfamily
Occurring in:
  1. Chaperonin GroEL
IPR027413
Domain description: GroEL-like equatorial domain superfamily
Occurring in:
  1. Chaperonin GroEL
IPR018370
Domain description: Chaperonin Cpn60, conserved site
Occurring in:
  1. Chaperonin GroEL
IPR002423
Domain description: Chaperonin Cpn60/GroEL/TCP-1 family
Occurring in:
  1. Chaperonin GroEL

Structure domains

CATH CATH domains
3.30.260.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GROEL; domain 2
Homology: TCP-1-like chaperonin intermediate domain
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 4hel contains 14 copies of CATH domain 3.30.260.10 (GROEL; domain 2) in Chaperonin GroEL. Showing 1 copy in chain A.
1.10.560.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: GROEL; domain 1
Homology: GroEL-like equatorial domain
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 4hel contains 14 copies of CATH domain 1.10.560.10 (GROEL; domain 1) in Chaperonin GroEL. Showing 1 copy in chain A.
3.50.7.10
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: GroEL
Homology: GroEL
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 4hel contains 14 copies of CATH domain 3.50.7.10 (GroEL) in Chaperonin GroEL. Showing 1 copy in chain A.

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