› 4h6y

X-ray diffraction
4.09Å resolution

Crystal structure of the DH-PH-PH domain of FARP1

Released:
DOI: 10.2210/pdb4h6y/pdb
PDB entry 4h6y coloured by chain, front view.
PDB entry 4h6y coloured by chain, side view.
PDB entry 4h6y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.
He X, Kuo YC, Rosche TJ, Zhang X
Structure 21 355-64 (2013)
PMID: 23375260

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195238 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FERM, ARHGEF and pleckstrin domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 501 amino acids
Theoretical weight: 57.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y4F1 (Residues: 539-1035; Coverage: 48%)
Gene names: CDEP, FARP1, PLEKHC2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P32
Unit cell:
a: 142.237Å b: 142.237Å c: 105.18Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.29 0.289 0.317
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Structural mechanisms of plexin signaling.
Pascoe et al. (2015)
4 more

6 mentions without citation

Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.
He et al. (2013)
5 more