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Influenza N2-Tyr406Asp neuraminidase in complex with beta-Neu5Ac

Source organism: Influenza A virus (A/RI/5+/1957(H2N2))
Biochemical function: exo-alpha-sialidase activity
Biological process: viral budding from plasma membrane
Cellular component: virion membrane

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00064
Domain description: Neuraminidase
Occurring in:
  1. Neuraminidase
The deposited structure of PDB entry 4h53 contains 4 copies of Pfam domain PF00064 (Neuraminidase) in Neuraminidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001860
Domain description: Glycoside hydrolase, family 34
Occurring in:
  1. Neuraminidase
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Neuraminidase
IPR033654
Domain description: Sialidase, Influenza viruses A/B
Occurring in:
  1. Neuraminidase

Structure domain

CATH CATH domain
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Neuraminidase
The deposited structure of PDB entry 4h53 contains 4 copies of CATH domain 2.120.10.10 (Neuraminidase) in Neuraminidase. Showing 1 copy in chain A.

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