Structure analysis

Crystal structure of human ERK2 complexed with a MAPK docking peptide

X-ray diffraction
2.2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules


Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 16700 Å2
Buried surface area: 2100 Å2
Dissociation area: 600 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -8 kcal/mol
Symmetry number: 1


Chain: A
Length: 362 amino acids
Theoretical weight: 41.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Pfam: Protein kinase domain

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Chain: B
Length: 13 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P36507 (Residues: 4-16; Coverage: 3%)
Gene names: MAP2K2, MEK2, MKK2, PRKMK2

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