PDBe 4guq

X-ray diffraction
3.7Å resolution

Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Tumor protein p73 Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15350 (Residues: 115-312; Coverage: 31%)
Gene names: P73, TP73
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3') Chains: E, F
Molecule details ›
Chains: E, F
Length: 10 nucleotides
Theoretical weight: 3.04 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P61
Unit cell:
a: 172.498Å b: 172.498Å c: 34.093Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.303 0.302 0.316
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided