Function and Biology

Crystal Structure of the Ni2+2-Human Arginase I-ABH complex

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: negative regulation of T-helper 2 cell cytokine production
Cellular component: specific granule lumen

EC 3.5.3.1: Arginase

Reaction catalysed:
L-arginine + H(2)O = L-ornithine + urea
Systematic name:
L-arginine amidinohydrolase
Alternative Name(s):
  • Arginine amidinase
  • Arginine transamidinase
  • Canavanase
  • L-arginase

Sequence family

Pfam Protein family (Pfam)
PF00491
Domain description: Arginase family
Occurring in:
  1. Arginase-1
The deposited structure of PDB entry 4gsv contains 2 copies of Pfam domain PF00491 (Arginase family) in Arginase-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006035
Domain description: Ureohydrolase
Occurring in:
  1. Arginase-1
IPR020855
Domain description: Ureohydrolase, manganese-binding site
Occurring in:
  1. Arginase-1
IPR014033
Domain description: Arginase
Occurring in:
  1. Arginase-1
IPR023696
Domain description: Ureohydrolase domain superfamily
Occurring in:
  1. Arginase-1

Structure domain

CATH CATH domain
3.40.800.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Arginase; Chain A
Homology: Ureohydrolase domain
Occurring in:
  1. Arginase-1
The deposited structure of PDB entry 4gsv contains 2 copies of CATH domain 3.40.800.10 (Arginase; Chain A) in Arginase-1. Showing 1 copy in chain A.