› 4gl1

X-ray diffraction
1.5Å resolution

Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant

Released:
DOI: 10.2210/pdb4gl1/pdb
PDB entry 4gl1 coloured by chain, front view.
PDB entry 4gl1 coloured by chain, side view.
PDB entry 4gl1 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: West DM

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: X
Molecule details ›
Chain: X
Length: 260 amino acids
Theoretical weight: 29.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 42.07Å b: 41.143Å c: 71.685Å
α: 90° β: 104.08° γ: 90°
R-values:
R R work R free
0.171 0.169 0.194
Expression system: Escherichia coli

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