Structure analysis

Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution

X-ray diffraction
2.55Å resolution
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 23100 Å2
Buried surface area: 3600 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -9 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 23300 Å2
Buried surface area: 3600 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -9 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 382 amino acids
Theoretical weight: 41.67 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: Q05086 (Residues: 400-417; Coverage: 2%)
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Gene names: E6AP, EPVE6AP, HPVE6A, JW3994, UBE3A, b4034, malE
Pfam: Bacterial extracellular solute-binding protein
InterPro:
CATH: Periplasmic binding protein-like II

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Chains: C, D
Length: 142 amino acids
Theoretical weight: 17.14 KDa
Source organism: Human papillomavirus type 16
Expression system: Escherichia coli
UniProt:
  • Canonical: P03126 (Residues: 9-150; Coverage: 90%)
Gene name: E6
Pfam: Early Protein (E6)
InterPro:
CATH: E6 early regulatory protein

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