PDBe 4gaw

X-ray diffraction
3Å resolution

Crystal structure of active human granzyme H

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Granzyme H Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 226 amino acids
Theoretical weight: 25.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20718 (Residues: 21-246; Coverage: 99%)
Gene names: CGL2, CTSGL2, GZMH
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21212
Unit cell:
a: 170.369Å b: 367.07Å c: 61.137Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.272 0.271 0.306
Expression system: Escherichia coli