X-ray diffraction
2.3Å resolution

Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor


Function and Biology Details

Reaction catalysed:
Palmitoyl-CoA + H(2)O = CoA + palmitate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Acyl-coenzyme A thioesterase THEM4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q5T1C6 (Residues: 40-240; Coverage: 84%)
Gene names: CTMP, THEM4
Sequence domains: Thioesterase superfamily
Structure domains: Hotdog Thioesterase

Ligands and Environments

Cofactor: Ligand 0ET 3 x 0ET
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 56.608Å b: 58.777Å c: 135.436Å
α: 90° β: 90° γ: 90°
R R work R free
0.19 0.19 0.257
Expression system: Escherichia coli