PDBe 4g85

X-ray diffraction
3.11Å resolution

Crystal structure of human HisRS


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Histidine--tRNA ligase, cytoplasmic Chains: A, B
Molecule details ›
Chains: A, B
Length: 517 amino acids
Theoretical weight: 58.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P12081 (Residues: 1-506; Coverage: 99%)
Gene names: HARS, HRS
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P41212
Unit cell:
a: 100.449Å b: 100.449Å c: 257.131Å
α: 90° β: 90° γ: 90°
R R work R free
0.274 0.271 0.327
Expression system: Escherichia coli BL21(DE3)