PDBe 4g83

X-ray diffraction
4Å resolution

Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Tumor protein p73 Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O15350 (Residues: 115-312; Coverage: 31%)
Gene names: P73, TP73
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
dna Chains: E, F
Molecule details ›
Chains: E, F
Length: 20 nucleotides
Theoretical weight: 6.13 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 141.717Å b: 96.345Å c: 34.348Å
α: 90° β: 90° γ: 90°
R R work R free
0.244 0.241 0.307
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided