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Structure of LGN GL4/Galphai3 complex

X-ray diffraction
3.481Å resolution
PDB entry 4g5r coloured by chain, front view.
PDB entry 4g5r coloured by chain, side view.
PDB entry 4g5r coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Guanine nucleotide-binding protein G(i) subunit alpha-3 and G-protein-signaling modulator 2
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Multimeric state: hetero dimer
Accessible surface area: 15636.07 Å2
Buried surface area: 3544.25 Å2
Dissociation area: 1,306.06 Å2
Dissociation energy (ΔGdiss): 10.4 kcal/mol
Dissociation entropy (TΔSdiss): 9.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140371
Assembly 2 (preferred)
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Assembly Name: Guanine nucleotide-binding protein G(i) subunit alpha-3 and G-protein-signaling modulator 2
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Multimeric state: hetero dimer
Accessible surface area: 15655.58 Å2
Buried surface area: 4373.68 Å2
Dissociation area: 1,446.26 Å2
Dissociation energy (ΔGdiss): 18.89 kcal/mol
Dissociation entropy (TΔSdiss): 9.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140371
Assembly 3
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Assembly Name: Guanine nucleotide-binding protein G(i) subunit alpha-3 and G-protein-signaling modulator 2
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Multimeric state: hetero dimer
Accessible surface area: 16183.51 Å2
Buried surface area: 4073.35 Å2
Dissociation area: 1,307.15 Å2
Dissociation energy (ΔGdiss): 14.81 kcal/mol
Dissociation entropy (TΔSdiss): 9.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140371
Assembly 4
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Assembly Name: Guanine nucleotide-binding protein G(i) subunit alpha-3 and G-protein-signaling modulator 2
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Multimeric state: hetero dimer
Accessible surface area: 16033.61 Å2
Buried surface area: 3205.31 Å2
Dissociation area: 1,235.31 Å2
Dissociation energy (ΔGdiss): 11.79 kcal/mol
Dissociation entropy (TΔSdiss): 9.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140371

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-3
Chains: A, B, C, D
Length: 330 amino acids
Theoretical weight: 37.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08754 (Residues: 25-354; Coverage: 93%)
Gene name: GNAI3
Pfam: G-protein alpha subunit
InterPro:
CATH:
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 4g5r, assembly 2, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 4g5r, assembly 2, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 4g5r, assembly 2, top view.
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G-protein-signaling modulator 2
Chains: E, F, G, Z
Length: 25 amino acids
Theoretical weight: 3.1 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q8VDU0 (Residues: 628-652; Coverage: 4%)
Gene names: Gpsm2, Lgn, Pins
Pfam: GoLoco motif
InterPro:
G-protein-signaling modulator 2 in PDB entry 4g5r, assembly 2, front view.
G-protein-signaling modulator 2 in PDB entry 4g5r, assembly 2, side view.
G-protein-signaling modulator 2 in PDB entry 4g5r, assembly 2, top view.
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