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Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.

Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE
Acta Crystallogr F Struct Biol Commun 71 609-14 (2015)
Related entries: 4f40, 4fzi, 4gie

Cited: 6 times
EuropePMC logo PMID: 25945716

Abstract

The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 Å for T. cruzi PGF, 1.25 Å for T. cruzi PGF with NADP, 1.6 Å for L. major PGF and 1.8 Å for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target.

Articles - 4g5d mentioned but not cited (4)

  1. Leishmania braziliensis prostaglandin F2α synthase impacts host infection. Alves-Ferreira EVC, Ferreira TR, Walrad P, Kaye PM, Cruz AK. Parasit Vectors 13 9 (2020)
  2. A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism. Roberts AJ, Dunne J, Scullion P, Norval S, Fairlamb AH. Biochem J 475 2593-2610 (2018)
  3. Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP. Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE. Acta Crystallogr F Struct Biol Commun 71 609-614 (2015)
  4. New Insights into the Role of the Trypanosoma cruzi Aldo-Keto Reductase TcAKR. Díaz-Viraqué F, Chiribao ML, Paes-Vieira L, Machado MR, Faral-Tello P, Tomasina R, Trochine A, Robello C. Pathogens 12 85 (2023)


Articles citing this publication (2)

  1. Polyunsaturated fatty acids alter the formation of lipid droplets and eicosanoid production in Leishmania promastigotes. Andrade YMFS, Castro MV, Tavares VS, Souza RDSO, Faccioli LH, Lima JB, Sorgi CA, Borges VM, Araújo-Santos T. Mem Inst Oswaldo Cruz 118 e220160 (2023)
  2. Transcriptome Analysis of Intracellular Amastigotes of Clinical Leishmania infantum Lines from Therapeutic Failure Patients after Infection of Human Macrophages. García-Hernández R, Perea-Martínez A, Manzano JI, Terrón-Camero LC, Andrés-León E, Gamarro F. Microorganisms 10 1304 (2022)


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