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Human topoisomerase iibeta in complex with DNA and mitoxantrone

X-ray diffraction
2.548Å resolution
PDB entry 4g0v coloured by chain, front view.
PDB entry 4g0v coloured by chain, side view.
PDB entry 4g0v coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA topoisomerase 2-beta and DNA
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Multimeric state: hetero hexamer
Accessible surface area: 62465.76 Å2
Buried surface area: 16019.53 Å2
Dissociation area: 2,569.58 Å2
Dissociation energy (ΔGdiss): 19.39 kcal/mol
Dissociation entropy (TΔSdiss): 16.31 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-117524

Macromolecules

DNA topoisomerase 2-beta
Chains: A, B
Length: 803 amino acids
Theoretical weight: 91.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02880 (Residues: 450-1206; Coverage: 47%)
Gene name: TOP2B
Pfam:
InterPro:
CATH:
DNA topoisomerase 2-beta in PDB entry 4g0v, assembly 1, front view.
DNA topoisomerase 2-beta in PDB entry 4g0v, assembly 1, side view.
DNA topoisomerase 2-beta in PDB entry 4g0v, assembly 1, top view.
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DNA chains C, E
Name: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3')
Representative chains: C, E
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.44 KDa
DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3') in PDB entry 4g0v, assembly 1, front view.
DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3') in PDB entry 4g0v, assembly 1, side view.
DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3') in PDB entry 4g0v, assembly 1, top view.
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DNA chains D, F
Name: DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3')
Representative chains: D, F
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.65 KDa
DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3') in PDB entry 4g0v, assembly 1, front view.
DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3') in PDB entry 4g0v, assembly 1, side view.
DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3') in PDB entry 4g0v, assembly 1, top view.
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