4fzi

X-ray diffraction
2.6Å resolution

Crystal structure of prostaglandin F synthase from Trypanosoma cruzi

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-175475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
9,11-endoperoxide prostaglandin H2 reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 290 amino acids
Theoretical weight: 33.59 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4DJ07 (Residues: 1-282; Coverage: 100%)
Gene name: Tc00.1047053511287.49
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 54.56Å b: 66.62Å c: 87.31Å
α: 90° β: 94.29° γ: 90°
R-values:
R R work R free
0.188 0.186 0.229
Expression system: Escherichia coli