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Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A

Source organism: Homo sapiens
Biochemical function: FAD-dependent H3K4me/H3K4me3 demethylase activity
Biological process: genomic imprinting
Cellular component: chromosome

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EC 1.14.99.66: [Histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase

Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + acceptor + H(2)O = a [histone H3]-N(6)-methyl-L-lysine(4) + formaldehyde + reduced acceptor
Systematic name:
[Histone H3]-N(6),N(6)-dimethyl-L-lysine(4):acceptor oxidoreductase (demethylating)
Alternative Name(s):
  • Lysine-specific histone demethylase 1

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01593
Domain description: Flavin containing amine oxidoreductase
Occurring in:
  1. Lysine-specific histone demethylase 2
The deposited structure of PDB entry 4fwe contains 1 copy of Pfam domain PF01593 (Flavin containing amine oxidoreductase) in Lysine-specific histone demethylase 2. Showing 1 copy in chain A.

PF04433
Domain description: SWIRM domain
Occurring in:
  1. Lysine-specific histone demethylase 2
The deposited structure of PDB entry 4fwe contains 1 copy of Pfam domain PF04433 (SWIRM domain) in Lysine-specific histone demethylase 2. Showing 1 copy in chain A.

PF07496
Domain description: CW-type Zinc Finger
Occurring in:
  1. Lysine-specific histone demethylase 2
The deposited structure of PDB entry 4fwe contains 1 copy of Pfam domain PF07496 (CW-type Zinc Finger) in Lysine-specific histone demethylase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Lysine-specific histone demethylase 2
IPR007526
Domain description: SWIRM domain
Occurring in:
  1. Lysine-specific histone demethylase 2
IPR011124
Domain description: Zinc finger, CW-type
Occurring in:
  1. Lysine-specific histone demethylase 2
IPR002937
Domain description: Amine oxidase
Occurring in:
  1. Lysine-specific histone demethylase 2
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Lysine-specific histone demethylase 2
IPR009057
Domain description: Homeobox-like domain superfamily
Occurring in:
  1. Lysine-specific histone demethylase 2

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