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Crystal Structure of the ERK2 complexed with E57

X-ray diffraction
2.5Å resolution
PDB entry 4fv6 coloured by chain, front view.
PDB entry 4fv6 coloured by chain, side view.
PDB entry 4fv6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 1
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Multimeric state: monomeric
Accessible surface area: 16269.7 Å2
Buried surface area: 585.04 Å2
Dissociation area: 80.85 Å2
Dissociation energy (ΔGdiss): 0.27 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151230

Macromolecules

Mitogen-activated protein kinase 1
Chain: A
Length: 360 amino acids
Theoretical weight: 41.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 1 in PDB entry 4fv6, assembly 1, front view.
Mitogen-activated protein kinase 1 in PDB entry 4fv6, assembly 1, side view.
Mitogen-activated protein kinase 1 in PDB entry 4fv6, assembly 1, top view.
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