› 4fu6

X-ray diffraction
2.1Å resolution

Crystal structure of the PSIP1 PWWP domain

Released:
DOI: 10.2210/pdb4fu6/pdb
PDB 4fu6 coloured by chain and viewed from the front.
PDB 4fu6 coloured by chain and viewed from the side.
PDB 4fu6 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Qin S, Tempel W, Xu C, Wu H, Dong A, Cerovina T, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75475 (Residues: 1-135; Coverage: 26%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand GOL 1 x GOL
Ligand UNX 5 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P43212
Unit cell:
a: 45.96Å b: 45.96Å c: 156.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

25 review citations

Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase.
Rathert P. (2021)
24 more

3 mentions without citation

Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains.
Weaver et al. (2018)
2 more