4ftg

X-ray diffraction
2.51Å resolution

The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Protein S100-A10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 96 amino acids
Theoretical weight: 11.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60903 (Residues: 2-97; Coverage: 99%)
Gene names: ANX2LG, CAL1L, CLP11, S100A10
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand
Annexin A2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 17 amino acids
Theoretical weight: 1.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P07355 (Residues: 2-16; Coverage: 4%)
Gene names: ANX2, ANX2L4, ANXA2, CAL1H, LPC2D
Neuroblast differentiation-associated protein AHNAK Chain: E
Molecule details ›
Chain: E
Length: 22 amino acids
Theoretical weight: 2.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q09666 (Residues: 5654-5673; Coverage: 0%)
Gene names: AHNAK, PM227

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 79.072Å b: 55.216Å c: 63.14Å
α: 90° β: 111.73° γ: 90°
R-values:
R R work R free
0.185 0.181 0.251
Expression systems:
  • Escherichia coli
  • Not provided