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Structure of the C-terminal domain of the Saccharomyces cerevisiae MUTL alpha (MLH1/PMS1) heterodimer bound to a fragment of exo1

X-ray diffraction
3.04Å resolution
PDB entry 4fmo coloured by chain, front view.
PDB entry 4fmo coloured by chain, side view.
PDB entry 4fmo coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MutLalpha endonuclease complex and Exodeoxyribonuclease 1
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Multimeric state: hetero trimer
Accessible surface area: 24388.63 Å2
Buried surface area: 4756.57 Å2
Dissociation area: 403.18 Å2
Dissociation energy (ΔGdiss): 1.14 kcal/mol
Dissociation entropy (TΔSdiss): 6.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146889

Macromolecules

DNA mismatch repair protein MLH1
Chain: A
Length: 288 amino acids
Theoretical weight: 33.24 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P38920 (Residues: 485-769; Coverage: 37%)
Gene names: MLH1, PMS2, YM8520.16, YMR167W
Pfam: DNA mismatch repair protein Mlh1 C-terminus
InterPro: DNA mismatch repair protein Mlh1, C-terminal
DNA mismatch repair protein MLH1 in PDB entry 4fmo, assembly 1, front view.
DNA mismatch repair protein MLH1 in PDB entry 4fmo, assembly 1, side view.
DNA mismatch repair protein MLH1 in PDB entry 4fmo, assembly 1, top view.
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DNA mismatch repair protein PMS1
Chain: B
Length: 240 amino acids
Theoretical weight: 27.95 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P14242 (Residues: 635-873; Coverage: 27%)
Gene names: N2317, PMS1, YNL082W
Pfam: MutL C terminal dimerisation domain
InterPro:
DNA mismatch repair protein PMS1 in PDB entry 4fmo, assembly 1, front view.
DNA mismatch repair protein PMS1 in PDB entry 4fmo, assembly 1, side view.
DNA mismatch repair protein PMS1 in PDB entry 4fmo, assembly 1, top view.
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Exodeoxyribonuclease 1
Chain: C
Length: 8 amino acids
Theoretical weight: 1.03 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Not provided
UniProt:
  • Canonical: P39875 (Residues: 443-450; Coverage: 1%)
Gene names: DHS1, EXO1, OR26.23, YOR033C
Exodeoxyribonuclease 1 in PDB entry 4fmo, assembly 1, front view.
Exodeoxyribonuclease 1 in PDB entry 4fmo, assembly 1, side view.
Exodeoxyribonuclease 1 in PDB entry 4fmo, assembly 1, top view.
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