EC 1.14.15.5: Corticosterone 18-monooxygenase
Reaction catalysed:
Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O
Systematic name:
Corticosterone,reduced-adrenodoxin:oxygen oxidoreductase (18-hydroxylating)
Alternative Name(s):
- Corticosterone 18-hydroxylase
- Corticosterone methyl oxidase
EC 1.14.15.4: Steroid 11-beta-monooxygenase
Reaction catalysed:
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H(2)O
Systematic name:
Steroid,reduced-adrenodoxin:oxygen oxidoreductase (11-beta-hydroxylating)
Alternative Name(s):
- Cytochrome p450 XIB1
- Steroid 11-beta-hydroxylase
- Steroid 11-beta/18-hydroxylase
GO terms
Biochemical function:
- corticosterone 18-monooxygenase activity
- metal ion binding
- heme binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- oxidoreductase activity
- steroid hydroxylase activity
- iron ion binding
- steroid 11-beta-monooxygenase activity
- monooxygenase activity
Biological process:
- organic hydroxy compound metabolic process
- cellular response to peptide hormone stimulus
- sodium ion homeostasis
- potassium ion homeostasis
- cellular response to potassium ion
- cortisol biosynthetic process
- cortisol metabolic process
- cellular response to hormone stimulus
- aldosterone biosynthetic process
- sterol metabolic process
- cholesterol metabolic process
- steroid metabolic process
- mineralocorticoid biosynthetic process
- glucocorticoid biosynthetic process
- C21-steroid hormone biosynthetic process
- steroid biosynthetic process
- lipid metabolic process
- renal water homeostasis
- regulation of blood volume by renal aldosterone
Protein family (Pfam)
InterPro annotations
CATH domain