X-ray diffraction
2.71Å resolution

Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole


Function and Biology Details

Reactions catalysed:
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H(2)O
Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytochrome P450 11B2, mitochondrial Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 483 amino acids
Theoretical weight: 55.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P19099 (Residues: 34-503; Coverage: 93%)
Gene name: CYP11B2
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

Cofactor: Ligand HEM 12 x HEM
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 129.751Å b: 199.086Å c: 150.018Å
α: 90° β: 112.08° γ: 90°
R R work R free
0.228 0.224 0.3
Expression system: Escherichia coli