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Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate

X-ray diffraction
2.65Å resolution
PDB entry 4f9o coloured by chain, front view.
PDB entry 4f9o coloured by chain, side view.
PDB entry 4f9o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Hexokinase-1
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Multimeric state: monomeric
Accessible surface area: 36686.8 Å2
Buried surface area: 1035.15 Å2
Dissociation area: 195.77 Å2
Dissociation energy (ΔGdiss): -1.01 kcal/mol
Dissociation entropy (TΔSdiss): 2.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148563
Assembly 2 (preferred)
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Assembly Name: Hexokinase-1
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Multimeric state: monomeric
Accessible surface area: 36530.94 Å2
Buried surface area: 1298.73 Å2
Dissociation area: 127.59 Å2
Dissociation energy (ΔGdiss): -4.86 kcal/mol
Dissociation entropy (TΔSdiss): 2.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148563

Macromolecules

Hexokinase-1
Chains: A, B
Length: 914 amino acids
Theoretical weight: 102.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19367 (Residues: 1-914; Coverage: 100%)
Gene name: HK1
Pfam:
InterPro:
CATH:
Hexokinase-1 in PDB entry 4f9o, assembly 2, front view.
Hexokinase-1 in PDB entry 4f9o, assembly 2, side view.
Hexokinase-1 in PDB entry 4f9o, assembly 2, top view.
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