› 4f9e

X-ray diffraction
2.75Å resolution

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

Released:
DOI: 10.2210/pdb4f9e/pdb
PDB entry 4f9e coloured by chain, front view.
PDB entry 4f9e coloured by chain, side view.
PDB entry 4f9e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cyclic di-GMP sensing via the innate immune signaling protein STING.
Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H
Mol Cell 46 735-45 (2012)
PMID: 22705373

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86WV6 (Residues: 139-379; Coverage: 64%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P43212
Unit cell:
a: 61.4Å b: 61.4Å c: 118.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

63 review citations

Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.
Römling et al. (2013)
62 more

9 mentions without citation

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.
Garland et al. (2022)
8 more