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- Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. J Biol Chem 288 33837-33847 (2013)
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- Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. He B, Hu J, Zhang X, Lin H. Org Biomol Chem 12 7498-7502 (2014)
- Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Pannek M, Simic Z, Fuszard M, Meleshin M, Rotili D, Mai A, Schutkowski M, Steegborn C. Nat Commun 8 1513 (2017)
- Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change. Yamagata K, Goto Y, Nishimasu H, Morimoto J, Ishitani R, Dohmae N, Takeda N, Nagai R, Komuro I, Suga H, Nureki O. Structure 22 345-352 (2014)
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- Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes. Rowland EA, Greco TM, Snowden CK, McCabe AL, Silhavy TJ, Cristea IM. mBio 8 e01096-17 (2017)
- Sirtuin Deacetylation Mechanism and Catalytic Role of the Dynamic Cofactor Binding Loop. Shi Y, Zhou Y, Wang S, Zhang Y. J Phys Chem Lett 4 491-495 (2013)
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- Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants. Kalous KS, Wynia-Smith SL, Summers SB, Smith BC. J Biol Chem 295 8524-8536 (2020)
- Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors. Liu S, Ji S, Yu ZJ, Wang HL, Cheng X, Li WJ, Jing L, Yu Y, Chen Q, Yang LL, Li GB, Wu Y. Chem Biol Drug Des 91 257-268 (2018)
- Dethioacylation by Sirtuins 1-3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition. Rajabi N, Nielsen AL, Olsen CA. ACS Med Chem Lett 11 1886-1892 (2020)
- Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. Nielsen AL, Rajabi N, Kudo N, Lundø K, Moreno-Yruela C, Bæk M, Fontenas M, Lucidi A, Madsen AS, Yoshida M, Olsen CA. RSC Chem Biol 2 612-626 (2021)
- Photo Cross-Linking Probes Containing ϵ-N-Thioacyllysine and ϵ-N-Acyl-(δ-aza)lysine Residues. Baek M, Martín-Gago P, Laursen JS, Madsen JLH, Chakladar S, Olsen CA. Chemistry 26 3862-3869 (2020)
- Development of Second Generation Activity-Based Chemical Probes for Sirtuins. Curry AM, Barton E, Kang W, Mongeluzi DV, Cen Y. Molecules 26 E11 (2020)
- Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme. Yu J, Haldar M, Mallik S, Srivastava DK. PLoS One 11 e0152467 (2016)
- Biophysical characterization of hit compounds for mechanism-based enzyme activation. Guan X, Upadhyay A, Munshi S, Chakrabarti R. PLoS One 13 e0194175 (2018)
- Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation. Wang ZA, Markert JW, Whedon SD, Yapa Abeywardana M, Lee K, Jiang H, Suarez C, Lin H, Farnung L, Cole PA. J Am Chem Soc 145 6811-6822 (2023)